Review



tlr8 agonist cl075  (InvivoGen)


Bioz Verified Symbol InvivoGen is a verified supplier
Bioz Manufacturer Symbol InvivoGen manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 95
      Buy from Supplier

    Structured Review

    InvivoGen tlr8 agonist cl075
    HuTLR8 induces fetal resorption and spontaneous pregnancy loss in Sle1 mice. A) C57Bl/6.huTLR8tg mice were crossed with Yaa males and then with Sle1 females . Sle1.huTLR8tg female mice express one (Sle1.huTLR8 +/- ) or two (Sle1.huTLR8 +/+ ) copies of the single human <t>TLR8</t> (huTLR8) transgenic locus. B. Outcomes of observed pregnancies. Adverse outcome was defined as maternal distress or death at delivery with evidence of an impacted pup or birth of dead or runted pups. p values calculated using Chi square analysis. C. I. An impacted pup in a Sle1.huTLR8 +/+ female II. An impacted pup together with an unaffected littermate; III. Representative uteri from Sle1 (top) and Sle1.huTLR8 +/+ (bottom) mice; IV. Growth retarded pup with an associated small placenta (*); V. A normal sized fetus and a resorbed fetus from the same pregnancy. D. Fetal weights (in gram) are depicted for full term Sle1 (n=5) and C57BL/6.huTLR8tg control live pregnancies and Sle1.huTLR8 +/- (n=16) and Sle1.huTLR8 +/+ (n=18) pregnancies with dystocia. Impacted/resorbed/dead fetuses are depicted in red. Maternal genotype and number of pregnancies are shown below the x axis. E, F. Total number of pups (E) and number of male (blue bars) and female (pink bars) pups (F) per live litter. Maternal genotype and number of pregnancies are shown below the x axis. Each symbol represents an individual pregnancy; bars represent the mean + SD. D-F: p values calculated using Kruskal Wallis ANOVA with Dunn’s correction for multiple analyses. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.
    Tlr8 Agonist Cl075, supplied by InvivoGen, used in various techniques. Bioz Stars score: 95/100, based on 229 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tlr8+agonist+cl075/bio_rxiv__64898__2026__02__07__701591-223-41-44?v=InvivoGen
    Average 95 stars, based on 229 article reviews
    tlr8 agonist cl075 - by Bioz Stars, 2026-08
    95/100 stars

    Images

    1) Product Images from "Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8"

    Article Title: Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8

    Journal: bioRxiv

    doi: 10.64898/2026.02.07.701591

    HuTLR8 induces fetal resorption and spontaneous pregnancy loss in Sle1 mice. A) C57Bl/6.huTLR8tg mice were crossed with Yaa males and then with Sle1 females . Sle1.huTLR8tg female mice express one (Sle1.huTLR8 +/- ) or two (Sle1.huTLR8 +/+ ) copies of the single human TLR8 (huTLR8) transgenic locus. B. Outcomes of observed pregnancies. Adverse outcome was defined as maternal distress or death at delivery with evidence of an impacted pup or birth of dead or runted pups. p values calculated using Chi square analysis. C. I. An impacted pup in a Sle1.huTLR8 +/+ female II. An impacted pup together with an unaffected littermate; III. Representative uteri from Sle1 (top) and Sle1.huTLR8 +/+ (bottom) mice; IV. Growth retarded pup with an associated small placenta (*); V. A normal sized fetus and a resorbed fetus from the same pregnancy. D. Fetal weights (in gram) are depicted for full term Sle1 (n=5) and C57BL/6.huTLR8tg control live pregnancies and Sle1.huTLR8 +/- (n=16) and Sle1.huTLR8 +/+ (n=18) pregnancies with dystocia. Impacted/resorbed/dead fetuses are depicted in red. Maternal genotype and number of pregnancies are shown below the x axis. E, F. Total number of pups (E) and number of male (blue bars) and female (pink bars) pups (F) per live litter. Maternal genotype and number of pregnancies are shown below the x axis. Each symbol represents an individual pregnancy; bars represent the mean + SD. D-F: p values calculated using Kruskal Wallis ANOVA with Dunn’s correction for multiple analyses. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.
    Figure Legend Snippet: HuTLR8 induces fetal resorption and spontaneous pregnancy loss in Sle1 mice. A) C57Bl/6.huTLR8tg mice were crossed with Yaa males and then with Sle1 females . Sle1.huTLR8tg female mice express one (Sle1.huTLR8 +/- ) or two (Sle1.huTLR8 +/+ ) copies of the single human TLR8 (huTLR8) transgenic locus. B. Outcomes of observed pregnancies. Adverse outcome was defined as maternal distress or death at delivery with evidence of an impacted pup or birth of dead or runted pups. p values calculated using Chi square analysis. C. I. An impacted pup in a Sle1.huTLR8 +/+ female II. An impacted pup together with an unaffected littermate; III. Representative uteri from Sle1 (top) and Sle1.huTLR8 +/+ (bottom) mice; IV. Growth retarded pup with an associated small placenta (*); V. A normal sized fetus and a resorbed fetus from the same pregnancy. D. Fetal weights (in gram) are depicted for full term Sle1 (n=5) and C57BL/6.huTLR8tg control live pregnancies and Sle1.huTLR8 +/- (n=16) and Sle1.huTLR8 +/+ (n=18) pregnancies with dystocia. Impacted/resorbed/dead fetuses are depicted in red. Maternal genotype and number of pregnancies are shown below the x axis. E, F. Total number of pups (E) and number of male (blue bars) and female (pink bars) pups (F) per live litter. Maternal genotype and number of pregnancies are shown below the x axis. Each symbol represents an individual pregnancy; bars represent the mean + SD. D-F: p values calculated using Kruskal Wallis ANOVA with Dunn’s correction for multiple analyses. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.

    Techniques Used: Transgenic Assay, Control



    Similar Products

    tlr8 agonist cl075  (InvivoGen)
    95
    InvivoGen tlr8 agonist cl075
    HuTLR8 induces fetal resorption and spontaneous pregnancy loss in Sle1 mice. A) C57Bl/6.huTLR8tg mice were crossed with Yaa males and then with Sle1 females . Sle1.huTLR8tg female mice express one (Sle1.huTLR8 +/- ) or two (Sle1.huTLR8 +/+ ) copies of the single human <t>TLR8</t> (huTLR8) transgenic locus. B. Outcomes of observed pregnancies. Adverse outcome was defined as maternal distress or death at delivery with evidence of an impacted pup or birth of dead or runted pups. p values calculated using Chi square analysis. C. I. An impacted pup in a Sle1.huTLR8 +/+ female II. An impacted pup together with an unaffected littermate; III. Representative uteri from Sle1 (top) and Sle1.huTLR8 +/+ (bottom) mice; IV. Growth retarded pup with an associated small placenta (*); V. A normal sized fetus and a resorbed fetus from the same pregnancy. D. Fetal weights (in gram) are depicted for full term Sle1 (n=5) and C57BL/6.huTLR8tg control live pregnancies and Sle1.huTLR8 +/- (n=16) and Sle1.huTLR8 +/+ (n=18) pregnancies with dystocia. Impacted/resorbed/dead fetuses are depicted in red. Maternal genotype and number of pregnancies are shown below the x axis. E, F. Total number of pups (E) and number of male (blue bars) and female (pink bars) pups (F) per live litter. Maternal genotype and number of pregnancies are shown below the x axis. Each symbol represents an individual pregnancy; bars represent the mean + SD. D-F: p values calculated using Kruskal Wallis ANOVA with Dunn’s correction for multiple analyses. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.
    Tlr8 Agonist Cl075, supplied by InvivoGen, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tlr8+agonist+cl075/bio_rxiv__64898__2026__02__07__701591-223-41-44?v=InvivoGen
    Average 95 stars, based on 1 article reviews
    tlr8 agonist cl075 - by Bioz Stars, 2026-08
    95/100 stars
    		  Buy from Supplier
    tlr8 agonists cl075  (MedChemExpress)
    94
    MedChemExpress tlr8 agonists cl075
    HuTLR8 induces fetal resorption and spontaneous pregnancy loss in Sle1 mice. A) C57Bl/6.huTLR8tg mice were crossed with Yaa males and then with Sle1 females . Sle1.huTLR8tg female mice express one (Sle1.huTLR8 +/- ) or two (Sle1.huTLR8 +/+ ) copies of the single human <t>TLR8</t> (huTLR8) transgenic locus. B. Outcomes of observed pregnancies. Adverse outcome was defined as maternal distress or death at delivery with evidence of an impacted pup or birth of dead or runted pups. p values calculated using Chi square analysis. C. I. An impacted pup in a Sle1.huTLR8 +/+ female II. An impacted pup together with an unaffected littermate; III. Representative uteri from Sle1 (top) and Sle1.huTLR8 +/+ (bottom) mice; IV. Growth retarded pup with an associated small placenta (*); V. A normal sized fetus and a resorbed fetus from the same pregnancy. D. Fetal weights (in gram) are depicted for full term Sle1 (n=5) and C57BL/6.huTLR8tg control live pregnancies and Sle1.huTLR8 +/- (n=16) and Sle1.huTLR8 +/+ (n=18) pregnancies with dystocia. Impacted/resorbed/dead fetuses are depicted in red. Maternal genotype and number of pregnancies are shown below the x axis. E, F. Total number of pups (E) and number of male (blue bars) and female (pink bars) pups (F) per live litter. Maternal genotype and number of pregnancies are shown below the x axis. Each symbol represents an individual pregnancy; bars represent the mean + SD. D-F: p values calculated using Kruskal Wallis ANOVA with Dunn’s correction for multiple analyses. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.
    Tlr8 Agonists Cl075, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tlr8+agonist+cl075/pmc05314176-276-35-48?v=MedChemExpress
    Average 94 stars, based on 1 article reviews
    tlr8 agonists cl075 - by Bioz Stars, 2026-08
    94/100 stars
    		  Buy from Supplier
    tlr8 agonists cl075  (InvivoGen)
    95
    InvivoGen tlr8 agonists cl075
    HuTLR8 induces fetal resorption and spontaneous pregnancy loss in Sle1 mice. A) C57Bl/6.huTLR8tg mice were crossed with Yaa males and then with Sle1 females . Sle1.huTLR8tg female mice express one (Sle1.huTLR8 +/- ) or two (Sle1.huTLR8 +/+ ) copies of the single human <t>TLR8</t> (huTLR8) transgenic locus. B. Outcomes of observed pregnancies. Adverse outcome was defined as maternal distress or death at delivery with evidence of an impacted pup or birth of dead or runted pups. p values calculated using Chi square analysis. C. I. An impacted pup in a Sle1.huTLR8 +/+ female II. An impacted pup together with an unaffected littermate; III. Representative uteri from Sle1 (top) and Sle1.huTLR8 +/+ (bottom) mice; IV. Growth retarded pup with an associated small placenta (*); V. A normal sized fetus and a resorbed fetus from the same pregnancy. D. Fetal weights (in gram) are depicted for full term Sle1 (n=5) and C57BL/6.huTLR8tg control live pregnancies and Sle1.huTLR8 +/- (n=16) and Sle1.huTLR8 +/+ (n=18) pregnancies with dystocia. Impacted/resorbed/dead fetuses are depicted in red. Maternal genotype and number of pregnancies are shown below the x axis. E, F. Total number of pups (E) and number of male (blue bars) and female (pink bars) pups (F) per live litter. Maternal genotype and number of pregnancies are shown below the x axis. Each symbol represents an individual pregnancy; bars represent the mean + SD. D-F: p values calculated using Kruskal Wallis ANOVA with Dunn’s correction for multiple analyses. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.
    Tlr8 Agonists Cl075, supplied by InvivoGen, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tlr8+agonist+cl075/pmc05314176-247-35-40?v=InvivoGen
    Average 95 stars, based on 1 article reviews
    tlr8 agonists cl075 - by Bioz Stars, 2026-08
    95/100 stars
    		  Buy from Supplier

    Image Search Results


    HuTLR8 induces fetal resorption and spontaneous pregnancy loss in Sle1 mice. A) C57Bl/6.huTLR8tg mice were crossed with Yaa males and then with Sle1 females . Sle1.huTLR8tg female mice express one (Sle1.huTLR8 +/- ) or two (Sle1.huTLR8 +/+ ) copies of the single human TLR8 (huTLR8) transgenic locus. B. Outcomes of observed pregnancies. Adverse outcome was defined as maternal distress or death at delivery with evidence of an impacted pup or birth of dead or runted pups. p values calculated using Chi square analysis. C. I. An impacted pup in a Sle1.huTLR8 +/+ female II. An impacted pup together with an unaffected littermate; III. Representative uteri from Sle1 (top) and Sle1.huTLR8 +/+ (bottom) mice; IV. Growth retarded pup with an associated small placenta (*); V. A normal sized fetus and a resorbed fetus from the same pregnancy. D. Fetal weights (in gram) are depicted for full term Sle1 (n=5) and C57BL/6.huTLR8tg control live pregnancies and Sle1.huTLR8 +/- (n=16) and Sle1.huTLR8 +/+ (n=18) pregnancies with dystocia. Impacted/resorbed/dead fetuses are depicted in red. Maternal genotype and number of pregnancies are shown below the x axis. E, F. Total number of pups (E) and number of male (blue bars) and female (pink bars) pups (F) per live litter. Maternal genotype and number of pregnancies are shown below the x axis. Each symbol represents an individual pregnancy; bars represent the mean + SD. D-F: p values calculated using Kruskal Wallis ANOVA with Dunn’s correction for multiple analyses. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.

    Journal: bioRxiv

    Article Title: Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8

    doi: 10.64898/2026.02.07.701591

    Figure Lengend Snippet: HuTLR8 induces fetal resorption and spontaneous pregnancy loss in Sle1 mice. A) C57Bl/6.huTLR8tg mice were crossed with Yaa males and then with Sle1 females . Sle1.huTLR8tg female mice express one (Sle1.huTLR8 +/- ) or two (Sle1.huTLR8 +/+ ) copies of the single human TLR8 (huTLR8) transgenic locus. B. Outcomes of observed pregnancies. Adverse outcome was defined as maternal distress or death at delivery with evidence of an impacted pup or birth of dead or runted pups. p values calculated using Chi square analysis. C. I. An impacted pup in a Sle1.huTLR8 +/+ female II. An impacted pup together with an unaffected littermate; III. Representative uteri from Sle1 (top) and Sle1.huTLR8 +/+ (bottom) mice; IV. Growth retarded pup with an associated small placenta (*); V. A normal sized fetus and a resorbed fetus from the same pregnancy. D. Fetal weights (in gram) are depicted for full term Sle1 (n=5) and C57BL/6.huTLR8tg control live pregnancies and Sle1.huTLR8 +/- (n=16) and Sle1.huTLR8 +/+ (n=18) pregnancies with dystocia. Impacted/resorbed/dead fetuses are depicted in red. Maternal genotype and number of pregnancies are shown below the x axis. E, F. Total number of pups (E) and number of male (blue bars) and female (pink bars) pups (F) per live litter. Maternal genotype and number of pregnancies are shown below the x axis. Each symbol represents an individual pregnancy; bars represent the mean + SD. D-F: p values calculated using Kruskal Wallis ANOVA with Dunn’s correction for multiple analyses. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.

    Article Snippet: Bone marrow neutrophils were isolated from 3– and 6-month-old homozygous female Sle1.huTLR8tg, Sle1 and C57BL/6 controls using EasySep mouse neutrophil enrichment kit (STEMCELL) and were treated with PMA 50nM for 4 hours at 37°C with or without pre-treatment with PMA or TLR8 agonist CL075 (Invivogen) 10mg/ml for 20 minutes.

    Techniques: Transgenic Assay, Control